ColdZyme Mouth & Throat Spray (Not Nasal Spray) - Cold Virus Treatment & Symptom Relief - Use at First Signs of a Cold - Menthol Flavour 20ml

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A 1–2 day reduction in a common cold episode is consistent with other treatments of common colds [ 23, 24], but also how often subjects were asked to assess the presence of illness in this trial (once a day). The assessment of symptom severity per Jackson score showed 11% less severe symptoms in the ColdZyme group (4. This indicates that the use of ColdZyme may be an easy and practical method for competitive athletes to alleviate and prevent or reduce infections of a naturally acquired common cold virus and corresponding unwanted absence from training and competition, if used at an early stage. and simultaneously experiencing a total Jackson score of at least 1 for any symptom except headache.

Jackson's symptom scale and the 9-item Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) quality of life (QoL) domain and a sore throat scale were recorded daily by subjects, as well as any use of allowed rescue treatment. Please be aware that in some instances your parcel may be delayed due to adverse weather on the route from our warehouse, even if your local area itself is not affected. The reduction in Jackson score area under the curve (AUC), where a lower value corresponds to fewer complaints and a higher value corresponds to more complaints, was likewise significantly reduced with ColdZyme treatment, although less discriminating than the 9-item WURSS-21 QoL domain. You can change your choices at any time by visiting Cookie preferences, as described in the Cookie notice. Lastly, the trypsin enzymes deactivate the virus particles preventing them from infecting cells, multiplying and spreading.If >3 days of cold were reported the previous week, reported days the following week were counted as belonging to the same incident. Content on this site is not intended to substitute for advice given by a medical practitioner, pharmacist, or other licensed health-care professional. Further, the study also supports findings from a study on naturally occurring upper respiratory tract infection (URTI) in competitive endurance athletes in which 123 endurance-trained, competitive athletes were randomized to control (no treatment, n = 61) or ColdZyme (n = 62) for a 3-month study period [ 19]. Jackson’s symptom scale and the 9-item Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) quality of life (QoL) domain and a sore throat scale were recorded daily by subjects, as well as any use of allowed rescue treatment.

When the participants who did not report any colds in the previous week were asked if they thought that ColdZyme had prevented them from catching a cold, the majority, 69% of participants, gave a positive answer ( Figure 2).

The primary endpoint was defined as the AUC for the WURSS-21 QoL composite sub-score assessed during the first 8 days of common cold symptoms (AUC WURSS21-QoL). The Jackson score was calculated by summing the scores for the following 8 symptoms: sore throat, blocked nose, runny nose, cough and sneezing (local symptoms) as well as headache, malaise, and chilliness (systemic symptoms).

From the first day of entering the treatment phase the subjects started to record their symptoms twice daily, in the morning and in the evening, on the Jackson scale [ 15] and once daily, in the evening, on the 9-item WURSS-21 QoL domain [ 16] and the Sore Throat Scale [ 17, 18].A positive difference between treatment groups was also seen for the subjects’ assessments of global efficacy of the investigational product, and a robust safety profile for ColdZyme was demonstrated throughout the study. After approval from four local Ethics Committees (Ethikkommission der Charité, Berlin; Landesärztekammer Brandenburg, Cottbus; Sächsische Landesärztekammer, Dresden; and Landesärztekammer Baden-Württemberg, Stuttgart) and after providing written informed consent, subjects were recruited to ten health care centers in Germany. Despite the increased risk in athletes, the number of reported colds in this evaluation is in line with the prevalence for a normal population, which is 2 - 4 incidents per subject and year, mostly during the winter [17] .